Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
序列
该CCND3 Recombinant Protein (Human)的序列请参考该产品的说明书
来源宿主
该CCND3 Recombinant Protein (Human)的来源宿主请参考该产品的说明书
溶解建议
该CCND3 Recombinant Protein (Human)的溶解建议请参考该产品的说明书
保存建议
该CCND3 Recombinant Protein (Human)的保存建议请参考该产品的说明书
其他
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