Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney (By similarity).
序列
该ERAP1 Recombinant Protein (Mouse)的序列请参考该产品的说明书
来源宿主
该ERAP1 Recombinant Protein (Mouse)的来源宿主请参考该产品的说明书
溶解建议
该ERAP1 Recombinant Protein (Mouse)的溶解建议请参考该产品的说明书
保存建议
该ERAP1 Recombinant Protein (Mouse)的保存建议请参考该产品的说明书
其他
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