中文名称

Delta-theraphotoxin-Hm1a Recombinant Protein (Togo starburst baboon spider)

英文名字

Delta-theraphotoxin-Hm1a Recombinant Protein (Togo starburst baboon spider)

供应商

Aviva Systems Biology

产品货号

aviva-OPCA04656-100UG

产品报价

￥询价/100ug

产品说明书

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产品新闻

背景资料

Gating modifier toxin that principally inhibits inactivation of the mammalian voltage-gated sodium channel Nav1.1/SCN1A. When tested against human Nav1.1/SCN1A-Nav1.8/SCN10A alpha subunits heterologously expressed in Xenopus oocytes, the toxin inhibits inactivation of Nav1.1 (EC(50)=38 nM), with substantially weaker effects on Nav1.2/SCN2A (EC(50)=236 nM) and Nav1.3/SCN3A (EC(50)=220 nM). The toxin inhibits several subtypes of voltage-gated potassium channels with significantly lower potency than its effects on Nav1.1/SCN1A (PubMed:27281198). It is a moderately potent blocker of Kv2.1/KCNB1, Kv2.2/KCNB2, Kv4.1/KCND1, Kv4.2/KCND2 and Kv4.3/KCND3 and has little effect on Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.3/KCNA3, Kv1.4/KCNA4, Kv1.5/KCNA5, Kv1.6/KCNA6 and Kv3.4/KCNC4 (PubMed:12065754). The binding affinity and subtype selectivity of the toxin is determined by residues within both the S1-S2 and S3-S4 loops of the domain IV voltage sensor (PubMed:27281198). Intracerebroventricular injection into mice elicits convulsions, spasms, tremors and rapid death (PubMed:12065754). When injected into mouse hindpaw, the toxin elicits an immediate and robust response to pain (PubMed:27281198). Intraplantar injection of toxin does not cause neurogenic inflammation or alter sensitivity to heat, indicative of a modality-specific effect on mechanosensitive neurons (PubMed:27281198).

序列

该Delta-theraphotoxin-Hm1a Recombinant Protein (Togo starburst baboon spider)的序列请参考该产品的说明书

来源宿主

该Delta-theraphotoxin-Hm1a Recombinant Protein (Togo starburst baboon spider)的来源宿主请参考该产品的说明书

溶解建议

该Delta-theraphotoxin-Hm1a Recombinant Protein (Togo starburst baboon spider)的溶解建议请参考该产品的说明书

保存建议

该Delta-theraphotoxin-Hm1a Recombinant Protein (Togo starburst baboon spider)的保存建议请参考该产品的说明书

其他

Aviva Systems Biology总部位于加利福尼亚州圣迭戈，在中国北京设有办公室，专注于为研究需求提供多克隆和单克隆抗体、ELISA试剂盒、蛋白质和定制服务。Aviva Systems Biology生产了24,000种经过验证的多克隆抗体，并提供近20,000种ELISA试剂盒，定制实验室服务包括蛋白表达和纯化、抗体开发，以及ELISA的开发、验证和生产。Aviva Systems Biology为与独特物种和靶标相关的研究提供独特工具，研究领域包括转录因子、癌症、心血管、细胞生物学、DNA损伤和修复、表观遗传学、信号转导、细胞分化、干细胞生物学等等。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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