Plays a central role in autophagy (PubMed:10604474, PubMed:12372286, PubMed:19270693, PubMed:28445460). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:19270693, PubMed:25275521). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (PubMed:25275521). Involved in endocytosis including endosome formation in neuronal cells (PubMed:25275521). May play a role in antiviral host defense (By similarity).
序列
该BECN1 Recombinant Protein (Mouse)的序列请参考该产品的说明书
来源宿主
该BECN1 Recombinant Protein (Mouse)的来源宿主请参考该产品的说明书
溶解建议
该BECN1 Recombinant Protein (Mouse)的溶解建议请参考该产品的说明书
保存建议
该BECN1 Recombinant Protein (Mouse)的保存建议请参考该产品的说明书
其他
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