This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.
序列
该P4HB Recombinant Protein (Chinese hamster)的序列请参考该产品的说明书
来源宿主
该P4HB Recombinant Protein (Chinese hamster)的来源宿主请参考该产品的说明书
溶解建议
该P4HB Recombinant Protein (Chinese hamster)的溶解建议请参考该产品的说明书
保存建议
该P4HB Recombinant Protein (Chinese hamster)的保存建议请参考该产品的说明书
其他
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