Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity (By similarity). Functions as tumor suppressor.
序列
该FHIT Recombinant Protein (Mouse)的序列请参考该产品的说明书
来源宿主
该FHIT Recombinant Protein (Mouse)的来源宿主请参考该产品的说明书
溶解建议
该FHIT Recombinant Protein (Mouse)的溶解建议请参考该产品的说明书
保存建议
该FHIT Recombinant Protein (Mouse)的保存建议请参考该产品的说明书
其他
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