Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
序列
该Protein E7 Recombinant Protein (Human)的序列请参考该产品的说明书
来源宿主
该Protein E7 Recombinant Protein (Human)的来源宿主请参考该产品的说明书
溶解建议
该Protein E7 Recombinant Protein (Human)的溶解建议请参考该产品的说明书
保存建议
该Protein E7 Recombinant Protein (Human)的保存建议请参考该产品的说明书
其他
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