Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).
序列
该MKI67 Recombinant Protein (Human)的序列请参考该产品的说明书
来源宿主
该MKI67 Recombinant Protein (Human)的来源宿主请参考该产品的说明书
溶解建议
该MKI67 Recombinant Protein (Human)的溶解建议请参考该产品的说明书
保存建议
该MKI67 Recombinant Protein (Human)的保存建议请参考该产品的说明书
其他
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