Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The toxin principally slows the inactivation process of TTX-sensitive sodium channels (PubMed:23685008). It is active on rat brain Nav1.2/SCN2A sodium channel (EC(50)=2.6 nM) and on rat skeletal muscle Nav1.4/SCN4A sodium channel (EC(50)=2.2 nM) (PubMed:12911331), as well as on human neuronal Nav1.7/SCN9A (EC(50)=6.8 nM) (PubMed:23685008). This toxin is active against mammals. In vivo, intraplantar injection into mice induces spontaneous pain responses (PubMed:23685008).
序列
该AaH2 Recombinant Protein的序列请参考该产品的说明书
来源宿主
Androctonus australis
溶解建议
该AaH2 Recombinant Protein的溶解建议请参考该产品的说明书
保存建议
该AaH2 Recombinant Protein的保存建议请参考该产品的说明书
其他
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