Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.
序列
该GNL3L Recombinant Protein的序列请参考该产品的说明书
来源宿主
Human
溶解建议
该GNL3L Recombinant Protein的溶解建议请参考该产品的说明书
保存建议
该GNL3L Recombinant Protein的保存建议请参考该产品的说明书
其他
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