Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334).
序列
该WDR77 Recombinant Protein的序列请参考该产品的说明书
来源宿主
Human
溶解建议
该WDR77 Recombinant Protein的溶解建议请参考该产品的说明书
保存建议
该WDR77 Recombinant Protein的保存建议请参考该产品的说明书
其他
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