Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes (PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398).
序列
该CEP63 Recombinant Protein的序列请参考该产品的说明书
来源宿主
Human
溶解建议
该CEP63 Recombinant Protein的溶解建议请参考该产品的说明书
保存建议
该CEP63 Recombinant Protein的保存建议请参考该产品的说明书
其他
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