Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.
序列
该E2 Recombinant Protein的序列请参考该产品的说明书
来源宿主
Human papillomavirus type 16
溶解建议
该E2 Recombinant Protein的溶解建议请参考该产品的说明书
保存建议
该E2 Recombinant Protein的保存建议请参考该产品的说明书
其他
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