Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Binds RNA which may help to stabilize the NELF complex on nucleic acid. In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1. May be able to induce chromatin unfolding.
序列
该Recombinant human Negative elongation factor B的序列请参考该产品的说明书
来源宿主
该Recombinant human Negative elongation factor B的来源宿主请参考该产品的说明书
溶解建议
该Recombinant human Negative elongation factor B的溶解建议请参考该产品的说明书
保存建议
该Recombinant human Negative elongation factor B的保存建议请参考该产品的说明书
其他
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