V-ATPase B1 is a protein encoded by the ATP6V1B1 gene which is approximately 56.8 kDa. V-ATPase B1 is localised to the endomembrane system. It is involved in insulin receptor recycling, innate immune system, metabolism and mTOR signalling pathway. It mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis and synaptic vesicle proton gradient generation. V-ATPase B1 is expressed in the cochlea and endolymphatic sac. Mutations in the ATP6V1B1 gene may result in renal tubular acidosis with progressive nerve deafness.
应用类型
WB, IHC
免疫原
Synthesized peptide derived from the C-terminal region of human V-ATPase B1. Location: 350-430aa.
来源宿主
Rabbit
反应性
该ATP6V1B1 抗体 - C-末端区域的反应性请参考该产品的说明书
保存建议
Store at -20C. Avoid repeated freeze/thaw cycles.
其他
Aviva Systems Biology总部位于加利福尼亚州圣迭戈，在中国北京设有办公室，专注于为研究需求提供多克隆和单克隆抗体、ELISA试剂盒、蛋白质和定制服务。Aviva Systems Biology生产了24,000种经过验证的多克隆抗体，并提供近20,000种ELISA试剂盒，定制实验室服务包括蛋白表达和纯化、抗体开发，以及ELISA的开发、验证和生产。Aviva Systems Biology为与独特物种和靶标相关的研究提供独特工具，研究领域包括转录因子、癌症、心血管、细胞生物学、DNA损伤和修复、表观遗传学、信号转导、细胞分化、干细胞生物学等等。
