The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
应用类型
WB
免疫原
Synthesized peptide derived from human TRBeta1 around the phosphorylation site of S142. Location: 90-170aa.
来源宿主
Rabbit
反应性
该THRB 抗体 (Phospho-Ser142)的反应性请参考该产品的说明书
保存建议
Store at -20C. Avoid repeated freeze/thaw cycles.
其他
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