JAK1 is a protein encoded by the JAK1 gene which is approximately 133,2 kDa. JAK1 is localised to the endomembrane system. It is involved in RET signalling, Th17 cell differentiation, influenza A and IL27-mediated signalling events. It is a membrane protein that is a member of a class of protein-tyrosine kinases characterized by the presence of a second phosphotransferase-related domain at the N-terminal to the PTK domain. It plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. JAK1 is expressed in the nervous system, liver, blood, spleen and lung. Mutations in the JAK1 gene may result in chilblain lupus and T-cell prolymphocytic leukemia. STJ90314 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous JAK1 protein which only binds about Y1022 when Y1022 is phosphorylated.
应用类型
WB, IHC
免疫原
Synthesized peptide derived between 960-1040 amino acids from human JAK1 around the phosphorylation site of Y1022
来源宿主
Rabbit
反应性
该JAK1 抗体 (Phospho-Tyr1022)的反应性请参考该产品的说明书
保存建议
Store at -20°C. Avoid repeated freeze/thaw cycles.
其他
Aviva Systems Biology总部位于加利福尼亚州圣迭戈，在中国北京设有办公室，专注于为研究需求提供多克隆和单克隆抗体、ELISA试剂盒、蛋白质和定制服务。Aviva Systems Biology生产了24,000种经过验证的多克隆抗体，并提供近20,000种ELISA试剂盒，定制实验室服务包括蛋白表达和纯化、抗体开发，以及ELISA的开发、验证和生产。Aviva Systems Biology为与独特物种和靶标相关的研究提供独特工具，研究领域包括转录因子、癌症、心血管、细胞生物学、DNA损伤和修复、表观遗传学、信号转导、细胞分化、干细胞生物学等等。
