NALCN (sodium leak channel non-selective protein), also known as Canlon or VGCNL1 (voltage gated channel-like protein 1) is a 1738 amino acid multi-pass membrane protein that belongs to the cation-nonselective channel family. NALCNis highly conserved in mammals and is widely expressed in the central nervous system. Activated by NK-1R, NALCN is a voltage-independent, nonselective cation channel which is permeable to sodium, potassium and calcium ions. NALCN is responsible for background sodium ion leak conductance in neurons and regulates basal excitability of the nervous systems. Defects of NALCN in mice causes disruption in respiratory rhythm and death occurs within 24 hours of birth. Three isoforms of NALCN exist due to alternative splicing events.
应用类型
WB, ICC, IF
免疫原
Fusion protein amino acids 1659-1738 (cytoplasmic C-terminus) of rat NALCN
来源宿主
Mouse
反应性
该NALCN 抗体的反应性请参考该产品的说明书
保存建议
Store at -20C. Shipping with Blue Ice or 4C.
其他
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