This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
应用类型
该Human ZAP-70 抗体 : HRP的应用类型请参考该产品的说明书
免疫原
Human ZAP-70 (a.a. 280-309)
来源宿主
Mouse
反应性
Human
保存建议
Store at 2-8C
其他
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