In vitro, TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEKs) 3, 4, and 6 toward their substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999; Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonists to the stress-responsive p38 MAPKs (Chen et al., 2003). Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain.
应用类型
WB
免疫原
Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser181 of TAO2.
来源宿主
Rabbit
反应性
该TAO2 抗体 (Phospho-Ser181)的反应性请参考该产品的说明书
保存建议
For long term storage -20C is recommended. Stable at -20C for at least 1 year.
其他
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