Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin43 is known to be regulated by phosphorylation at Ser368 by protein kinase C (Yogo et al., 2002; Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin43 that results in a decrease in gap junction permeability (Bao et al., 2004b).
应用类型
WB
免疫原
Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser368 of rat connexin43.
来源宿主
Rabbit
反应性
该Connexin43 抗体 (Phospho-Ser368)的反应性请参考该产品的说明书
保存建议
Store at -20C; stable for at least one year.
其他
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