GLRA1 抗体-GLRA1 Antibody代理/参数/厂家-一抗-艾美捷科技有限公司

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背景资料: Glycine is an important inhibitory transmitter in the brainstem and spinal cord. Glycine receptors are members of the ligand-gated ion channel family (LGICs) that mediate rapid chemical neurotransmission (Schofield et al., 2003). The binding of glycine to its receptor produces a large increase in chloride conductance, which causes membrane hyperpolarization. Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein, gephyrin (Fischer et al., 2000). The glycine receptor has been used to great advantage in the identification of the binding sites for alcohol on the LGIC family of proteins (Beckstead et al., 2001; Mihic et al., 1997). These receptors have also been extremely useful in studies of synaptic clustering of receptors (Craig and Lichtman, 2001). The glycine receptor may also act in concert with an NMDAR subunit to form an excitatory receptor (Chatterton et al., 2002).

免疫原: Peptide from the N-terminus region of the alpha 1-subunit of rat glycine receptor.

保存建议: Packaging: 200 ug antibody vial; lyophilized from 5 mM ammonium bicarbonate.Adequate amount of material to conduct 10-mini Western Blots.
Reconstitution: The antibody should be reconstituted in 100 ul phosphate buffered saline (PBS: 137 mM NaCl, 7.5 mM Na2HPO4, 2.7 mM KCl, 1.5 mM KH2HPO4, pH 7.4) before use.
Storage: After reconstitution the antibody should be aliquoted and stored at -20C.

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