MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS (5,6). The specificity of this response is determined by the species of MD-2; e.g., human MD-2 can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4 (7).
应用类型
WB, IHC-P
免疫原
Rabbit polyclonal MD-2 antibody was raised against a peptide corresponding to amino acids near the middle region of human MD-2.
来源宿主
Rabbit
反应性
该LY96 抗体的反应性请参考该产品的说明书
保存建议
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles. Products are stable for one year from purchase when stored properly.
其他
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