- 中文名称
RpS27A 抗体
- 英文名字
- RpS27A Antibody
- 供应商
- Aviva Systems Biology
- 产品货号
- aviva-OAED00134-50UG
- 产品报价
- ￥询价/50ug
- 产品说明书
- 点击查看
- 购买方式
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- 产品新闻
- 背景资料
- Ubiquitin is a 76-amino acid polypeptide expressed in all eukaryotic cells, highly conserved from yeast to humans. The modification of proteins by chains of ubiquitin mediates targeting of cytosolic and nuclear proteins for degradation by proteasomes. Ubiquitination represents an essential cellular process affected by a multi-enzyme cascade involving classes of enzymes known as ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s or Ubcs) and ubiquitin-protein ligases (E3s). E1 activates ubiquitin in an ATP-dependent manner with the formation of a thiol-ester linkage between the carboxy terminus of ubiquitin and E1. Sequential, transient thiol-ester bonds then generate between the carboxyl terminus of ubiquitin and specific cysteines of E2 and E3 enzymes. These bonds culminate in the formation of an isopeptide linkage between the activated carboxy terminus of ubiquitin and the epsilon-amino group of a lysine on a target protein, or within another ubiquitin chain (usually K48 of ubiquitin) resulting in the generation of chains of ubiquitin (polyubiquitin or multiubiquitin) from 4-20 ubiquitin moieties. Although the formation of K48-linked polyubiquitin chains on proteins constitutes a potent targeting signal for degradation in 26S proteasomes, ubiquitination is also reversible, and a number of not fully characterized deubiquitinating enzymes exist free in the cytosol. Research exploring how proteasome targets ER-retained proteins for degradation suggests that ER chaperones (such as Cne1p/calnexin, Kar2p/BiP or other components of the protein processing or transport machineries) helped by cytosolic chaperones (such as members of the Hsp70 and DnaJ families) recognize, target and force misfolded, unassembled or aberrantly modified proteins through the translocon. The retrotranslocated polypeptide chains are then released into the cytosol as soluble proteins or remain adhered to the cytosolic face of the ER membrane where deglycosylation and polyubiquitination followed by binding to the proteasome as well as degradation to peptides occurs. Ubiquitination also participates in the internalization and degradation of plasma membrane proteins such as some of the TCR subunits while still ER-membrane associated.
- 应用类型
- FC
- 免疫原
- Native bovine Ubiquitin.
- 来源宿主
- Rabbit
- 反应性
- 该RpS27A 抗体的反应性请参考该产品的说明书
- 保存建议
- Long Term Storage : -20C
- 其他
- Aviva Systems Biology总部位于加利福尼亚州圣迭戈，在中国北京设有办公室，专注于为研究需求提供多克隆和单克隆抗体、ELISA试剂盒、蛋白质和定制服务。Aviva Systems Biology生产了24,000种经过验证的多克隆抗体，并提供近20,000种ELISA试剂盒，定制实验室服务包括蛋白表达和纯化、抗体开发，以及ELISA的开发、验证和生产。Aviva Systems Biology为与独特物种和靶标相关的研究提供独特工具，研究领域包括转录因子、癌症、心血管、细胞生物学、DNA损伤和修复、表观遗传学、信号转导、细胞分化、干细胞生物学等等。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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