ADP-ribosylation factors (ARF) are a ubiquitous family of GTP-binding proteins involved in membrane dynamics and vesicular trafficking. The ARF family also includes the structurally related ARF-like proteins. ARF family members possess a highly conserved structure and function in eukaryotes. ARFs function as essential proteins in Saccharomyces cerevisiae (ARF-1 and ARF-2) and in Drosophila melanogaster (ARF-like). Many studies associate ARF proteins with exocytic and endocytic transport pathways, and the activation of phospholipase D activity. ARF-1, an abundantly expressed Ras-like N-myristoylated GTP-binding protein, co-purifies with tightly bound GDP. ARF possesses an extra beta-strand (beta2E) and N-terminal helix, two structural elements missing in Ras. Like Ras, ARF-1 switches between the GTP-bound "on†state where it transfers signals to its effectors in the signaling pathway, and the GDP-bound "off†state.
应用类型
WB
免疫原
Synthetic peptide corresponding to the sequence near the C-terminus of human ARF1.
来源宿主
Mouse
反应性
该Anti-ARF1 (ARFS 3F1) 抗体的反应性请参考该产品的说明书
保存建议
Long Term Storage : -20C
其他
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