Bone morphogenic protein 4 (BMP4) is a member of the TGF-beta superfamily that plays a critical role in mammalian mesenchymal development, influencing hematopoeisis and osteoblast differentiation and function. BMP-4 is secreted as 54 kDa inactive precursor peptides that dimerize and are activated following cleavage by members of the proprotein convertase family. Active BMP-4 binds type I and type II serine/threonine kinase receptors which signal via phosphorylation of Smad family proteins. BMP-4 and the highly homologous BMP-2 are functional orthologues of the decapentaplegic (dpp) gene in Drosophila that regulates embryonic leg and wing imaginal disc patterning and larval gut development.
应用类型
WB
免疫原
Recombinant full length human BMP4.
来源宿主
Mouse
反应性
该Anti-BMP4 (26H16) 抗体的反应性请参考该产品的说明书
保存建议
Long Term Storage : -20C
其他
Aviva Systems Biology总部位于加利福尼亚州圣迭戈，在中国北京设有办公室，专注于为研究需求提供多克隆和单克隆抗体、ELISA试剂盒、蛋白质和定制服务。Aviva Systems Biology生产了24,000种经过验证的多克隆抗体，并提供近20,000种ELISA试剂盒，定制实验室服务包括蛋白表达和纯化、抗体开发，以及ELISA的开发、验证和生产。Aviva Systems Biology为与独特物种和靶标相关的研究提供独特工具，研究领域包括转录因子、癌症、心血管、细胞生物学、DNA损伤和修复、表观遗传学、信号转导、细胞分化、干细胞生物学等等。
