- 中文名称
Anti-AEG1 抗体 (Phospho-SER568)
- 英文名字
- Anti-AEG1 Antibody (Phospho-SER568)
- 供应商
- Aviva Systems Biology
- 产品货号
- aviva-OAAI00784-100UG
- 产品报价
- ￥询价/100ug
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系。本公司所有产品仅供科研使用，不用于临床诊断。
- 产品新闻
- 背景资料
- AEG1 (Astrocyte elevated gene 1), also called MTDH (Metadherin), or L LYsine-RIch CEACAM1 co-isolated (LYRIC), is 582 aa single transmembrane domain (TMD) protein. It is widely expressed and highly conserved between species. It is recruited during the matuRation of the tight junction complex and co-localizes with tight junction proteins ZO-1 and occludin in polarized epithelial cells. AEG-1 is involved in several crucial aspects of tumor progression, including transformation, evasion of apoptosis, invasion, metastasis, and chemoresistance. Overexpression of AEG-1 is frequently observed in melanoma, glioma, neuroblastoma, and carcinomas of breast, prostate, liver, and esophagus and is correlated with poor clinical outcomes. AEG-1 functions as a downstream mediator of the transforming activity of oncogenic Ha-Ras and c-Myc.
Furthermore, AEG-1 overexpression activates the PI3K/Akt, nuclear factor κB (NFκB), and Wnt/beta-catenin signaling pathways to stimulate prolifeRation, invasion, cell survival, and chemoresistance. The lung-homing domain of AEG-1 also mediates the adhesion of tumor cells to the vasculature of distant organs and promotes metastasis. These findings sμggest that therapeutic targeting of AEG-1 may simultaneously suppress tumor growth, block metastasis, and enhance the efficacy of chemotherapeutic treatments.
- 应用类型
- Enzyme-linked immunosorbent assay|Flow cytometry|Immunohistochemistry|Immunoprecipitation|Western blot
- 免疫原
- A synthetic peptide derived from a phosphrylation site of serine 568 surrounding the epitope -TSWESPKQI-of human AEG1. This sequence is identical to human, mouse, rat and bovine.
- 来源宿主
- Rabbit
- 反应性
- 该Anti-AEG1 抗体 (Phospho-SER568)的反应性请参考该产品的说明书
- 保存建议
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- 其他
- Aviva Systems Biology总部位于加利福尼亚州圣迭戈，在中国北京设有办公室，专注于为研究需求提供多克隆和单克隆抗体、ELISA试剂盒、蛋白质和定制服务。Aviva Systems Biology生产了24,000种经过验证的多克隆抗体，并提供近20,000种ELISA试剂盒，定制实验室服务包括蛋白表达和纯化、抗体开发，以及ELISA的开发、验证和生产。Aviva Systems Biology为与独特物种和靶标相关的研究提供独特工具，研究领域包括转录因子、癌症、心血管、细胞生物学、DNA损伤和修复、表观遗传学、信号转导、细胞分化、干细胞生物学等等。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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