The 280-330kDa Notch protein is a single transmembrane receptor which is expressed on a range of cells including hematopoietic cells in Mouse fetal liver, adult thymus and bone marrow. These proteins have been found to be overexpressed or rearranged in Human tumors. It functions as a receptor for membrane-bound ligands Jagged1, Jagged-2 and Delta1 to regulate cell-fate determination. Following ligand binding, Notch 1 is cleaved in the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus, where it plays a role in the modulation of gene expression. Notch1 plays a role in embryonic development and tissue homeostasis in the adult. Recent work has sμggested a further role for this receptor in the regulation of lymphopoieisis and myelopoiesis.
应用类型
Enzyme-linked immunosorbent assay|Flow cytometry|Immunohistochemistry|Immunoprecipitation|Western blot
免疫原
A synthetic peptide derived from C-terminus of human Notch 1.
来源宿主
Rabbit
反应性
该Anti-Notch 1 Polyclonal 抗体的反应性请参考该产品的说明书
保存建议
The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
其他
Aviva Systems Biology总部位于加利福尼亚州圣迭戈，在中国北京设有办公室，专注于为研究需求提供多克隆和单克隆抗体、ELISA试剂盒、蛋白质和定制服务。Aviva Systems Biology生产了24,000种经过验证的多克隆抗体，并提供近20,000种ELISA试剂盒，定制实验室服务包括蛋白表达和纯化、抗体开发，以及ELISA的开发、验证和生产。Aviva Systems Biology为与独特物种和靶标相关的研究提供独特工具，研究领域包括转录因子、癌症、心血管、细胞生物学、DNA损伤和修复、表观遗传学、信号转导、细胞分化、干细胞生物学等等。
