Dsg3 and Dsg1 are members of the desmosomal cadherins that provide adhesive integrity to desmosomes between adjoining keRatinocytes; the former distributes primarily in the deeper epidermis, whereas the latter is localized to the superficial epidermis. This distribution profile of these target antigens,Dsg3 and Dsg1, of PV (Pemphigus Vulgaris ) and pemphigus foliaceus autoantibodies explains the characteristic clinical features and histopathological localization of acantholysis in their respective diseases. Dsg3 plays important roles in cell-cell adhesion in PV-autoimmune disease as well as in Human squamous cell cancer. The level of Dsg3 can be used as a read-out of pathogenic changes.
应用类型
Enzyme-linked immunosorbent assay|Flow cytometry|Immunohistochemistry|Immunoprecipitation|Western blot
免疫原
The recombinant protein of human Desmoglein-3 extracellular domain.
The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
其他
Aviva Systems Biology总部位于加利福尼亚州圣迭戈，在中国北京设有办公室，专注于为研究需求提供多克隆和单克隆抗体、ELISA试剂盒、蛋白质和定制服务。Aviva Systems Biology生产了24,000种经过验证的多克隆抗体，并提供近20,000种ELISA试剂盒，定制实验室服务包括蛋白表达和纯化、抗体开发，以及ELISA的开发、验证和生产。Aviva Systems Biology为与独特物种和靶标相关的研究提供独特工具，研究领域包括转录因子、癌症、心血管、细胞生物学、DNA损伤和修复、表观遗传学、信号转导、细胞分化、干细胞生物学等等。
