- 中文名称
Anti-C-erbB-4/HER-4 Monoclonal 抗体
- 英文名字
- Anti-C-erbB-4/HER-4 Monoclonal Antibody
- 供应商
- Aviva Systems Biology
- 产品货号
- aviva-OAAI00283-100UG
- 产品报价
- ￥询价/100ug
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系。本公司所有产品仅供科研使用，不用于临床诊断。
- 产品新闻
- 背景资料
- The HER4/ERBB4 belongs to a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. This gene encodes a 180K a single-pass type I transmembrane protein (HER4/p180erbB4) with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif, This protein is structurally related to the 185K product (HER2/p 185erbB2) of the HER2/ERBB2 proto-oncogene, and is activated by neuregulins, A 45K heparin-binding glycoprotein (p45), and other factors can specifically activates the intrinsic tyrosine kinase activity of HER4 and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. This HER4 ligand shares several features with the heregulin family of proteins, including molecular mass, ability to induce differentiation of breast cancer cells, activation of tyrosine phosphorylation in MDA-MB453 cells, and amino-terminal protein sequence. Mutations in this gene have been associated with cancer.
- 应用类型
- Enzyme-linked immunosorbent assay|Flow cytometry|Immunohistochemistry|Immunoprecipitation|Western blot
- 免疫原
- A synthetic peptide corresponding to the C-terminus of Her4 protein. This sequence is identical in human and mouse.
- 来源宿主
- Mouse
- 反应性
- 该Anti-C-erbB-4/HER-4 Monoclonal 抗体的反应性请参考该产品的说明书
- 保存建议
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- 其他
- Aviva Systems Biology总部位于加利福尼亚州圣迭戈，在中国北京设有办公室，专注于为研究需求提供多克隆和单克隆抗体、ELISA试剂盒、蛋白质和定制服务。Aviva Systems Biology生产了24,000种经过验证的多克隆抗体，并提供近20,000种ELISA试剂盒，定制实验室服务包括蛋白表达和纯化、抗体开发，以及ELISA的开发、验证和生产。Aviva Systems Biology为与独特物种和靶标相关的研究提供独特工具，研究领域包括转录因子、癌症、心血管、细胞生物学、DNA损伤和修复、表观遗传学、信号转导、细胞分化、干细胞生物学等等。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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