This gene is a member of the cysteine-aspartic acid protease (caspase) family. Alternative splicing of this gene results in two transcript variants that encode the same protein. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases-3 exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspases-3 cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10
应用类型
WB, IF, IHC
免疫原
This Aviva monoclonal antibody is produced by immunizing mice with recombinant polypeptide (Aviva SEAL mAb technology) corresponding to surface multi-epitopes of human Caspase-3.
来源宿主
Mouse
反应性
该CASP3 抗体的反应性请参考该产品的说明书
保存建议
Store the product at -20C. Stable for one year from the date of shipment.
其他
Aviva Systems Biology总部位于加利福尼亚州圣迭戈，在中国北京设有办公室，专注于为研究需求提供多克隆和单克隆抗体、ELISA试剂盒、蛋白质和定制服务。Aviva Systems Biology生产了24,000种经过验证的多克隆抗体，并提供近20,000种ELISA试剂盒，定制实验室服务包括蛋白表达和纯化、抗体开发，以及ELISA的开发、验证和生产。Aviva Systems Biology为与独特物种和靶标相关的研究提供独特工具，研究领域包括转录因子、癌症、心血管、细胞生物学、DNA损伤和修复、表观遗传学、信号转导、细胞分化、干细胞生物学等等。
