- 中文名称
Anti- Stathmin 1 (Phospho-Ser16) 抗体
- 英文名字
- Anti- Stathmin 1 (Phospho-Ser16) Antibody
- 供应商
- Aviva Systems Biology
- 产品货号
- aviva-GWB-B00CF2-100UG
- 产品报价
- ￥询价/100ug
- 产品说明书
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- 产品新闻
- 背景资料
- Binding Site: Ser15 WB Dilution: 500~1000
IHC Dilution: 50~100 Function: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis.
Subunit: Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST.
Subcellular Location: Cytoplasm.
Tissue Specificity: Ubiquitous. Highest levels in brain, neurons, testis and leukemic lymphocytes.
Ptm: Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.
Disease: Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.
Similarity: Belongs to the stathmin family. [1] Zhu X.-X., Kozarsky K., Strahler J.R., Eckerskorn C., Lottspeich F., Melhem R., Lowe J., Fox D.A., Hanash S.M., Atweh G.F., et al.
Molecular cloning of a novel human leukemia-associated gene. Evidence of conservation in animal species.
[2] Maucuer A., Doye V., Sobel A.
A single amino acid difference distinguishes the human and the rat sequences of stathmin, a ubiquitous intracellular phosphoprotein associated with cell regulations.
[3] Melhem R.F., Zhu X., Hailat N., Strahler J.R., Hanash S.M.
Characterization of the gene for a proliferation-related phosphoprotein (oncoprotein 18) expressed in high amounts in acute leukemia.
[4] Hosoya H., Ishikawa K., Dohi N., Marunouchi T.
Transcriptional and post-transcriptional regulation of pr22 (Op18) with proliferation control.
[5] Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., et al.
The DNA sequence and biological annotation of human chromosome 1.
[6] Lubec G., Vishwanath V.
Submitted (MAR-2007) to UniProtKB.
[7] Hanash S.M., Strahler J.R., Kuick R., Chu E.H.Y., Nichols D.
Ca2+-dependent and cAMP-dependent control of nicotinic acetylcholine receptor phosphorylation in muscle cells.
[8] Labdon J.E., Nieves E., Schubart U.K.
Analysis of phosphoprotein p19 by liquid chromatography/mass spectrometry. Identification of two proline-directed serine phosphorylation sites and a blocked amino terminus.
[9] Marklund U., Brattsand G., Shingler V., Gullberg M.
Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase.
[10] Marklund U., Brattsand G., Osterman O., Ohlsson P.-I., Gullberg M.
Multiple signal transduction pathways induce phosphorylation of serines 16, 25, and 38 of oncoprotein 18 in T lymphocytes.
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- 反应性
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- 保存建议
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- 其他
- Aviva Systems Biology总部位于加利福尼亚州圣迭戈，在中国北京设有办公室，专注于为研究需求提供多克隆和单克隆抗体、ELISA试剂盒、蛋白质和定制服务。Aviva Systems Biology生产了24,000种经过验证的多克隆抗体，并提供近20,000种ELISA试剂盒，定制实验室服务包括蛋白表达和纯化、抗体开发，以及ELISA的开发、验证和生产。Aviva Systems Biology为与独特物种和靶标相关的研究提供独特工具，研究领域包括转录因子、癌症、心血管、细胞生物学、DNA损伤和修复、表观遗传学、信号转导、细胞分化、干细胞生物学等等。
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