SLC27A2 Polyclonal 抗体 (Human)-SLC27A2 Polyclonal Antibody (Human)代理/参数/厂家-一抗-艾美捷科技有限公司

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背景资料: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake (PubMed:20530735, PubMed:22022213, PubMed:24269233, PubMed:10198260, PubMed:10749848, PubMed:11980911).rnAlso functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:20530735, PubMed:22022213, PubMed:24269233, PubMed:10198260, PubMed:10749848, PubMed:11980911).rnPlays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis (PubMed:20530735).rnCan also activate branched-chain fatty acids such as phytanic acid and pristanic acid (PubMed:10198260).rnMay contribute to the synthesis of sphingosine-1-phosphate (PubMed:24269233).rnDoes not activate C24 bile acids, cholate and chenodeoxycholate (PubMed:11980911).rnIn vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911).rnHowever, it is not critical for THCA activation and bile synthesis in vivo (PubMed:20530735).

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