- 中文名称
Vascular Endothelial Growth Factor B (VEGFB) Antibody
- 英文名字
- Vascular Endothelial Growth Factor B (VEGFB) Antibody
- 供应商
- Abbexa
- 产品货号
- abx117220
- 产品报价
- ￥询价/100ug
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868。
- 产品新闻
- 背景资料
- VEGFB Antibody is a Rabbit Polyclonal antibody against VEGFB. Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular endothelial cellsVEGF and its close relatives VEGF-B, -C and -D form a subfamily within PDGF family of growth factors, which belongs to the cysteine knot class of cytokinesFive VEGF isoforms of 121, 145, 165, 189 and 206 amino acids (VEGF121–206) are geneRated as a result of alternative splicing from a single VEGF geneThe various VEGF forms bind to three tyrosine-kinase receptors, VEGFR-1, VEGFR-2 and VEGFR-3 which are expressed almost exclusively in endothelial cellsVEGFR-2 is the main angiogenic signal transducer for VEGF, while VEGFR-3 is specific for VEGF-C and -D and is necessary and sufficient for lymphangiogenic signalingHowever, upon proteolytic processing VEGF-C and -D gain the ability to also bind and activate VEGFR-2Guided by the binding properties of the ligands, the VEGFRs are able to form both homodimers and heterodimersReceptor dimerization is accompanied by activation of receptor kinase activity leading to receptor autophosphorylationPhosphorylated receptors recruit interacting proteins and induce downstream signalingRecently, tumor therapies based on neutralizing anti-VEGF antibodies and small molecule tyrosine kinase inhibitors targeting VEGFRs have been developedThese new stRategies for tumor treatment show the clinical relevance of inhibiting VEGF signal transduction pathways that are exaggeRated in pathological angiogenesisThis protein is involved in Cancer.
- 应用类型
- ELISA, WB, IHC
- 免疫原
- VEGFB
- 来源宿主
- 兔
- 反应性
- 人，小鼠，大鼠
- 保存建议
- 建议收到该Vascular Endothelial Growth Factor B (VEGFB) Antibody产品后，储存温度为-20°C。避免重复冻融
- 其他
- Abbexa总部位于英国剑桥的剑桥科学园,是一家专业的全球抗体供应商和蛋白质供应商,致力于为生命科学、药物开发和生物技术领域的科学家和研究者提供最佳的客户体验和高质量的产品。产品涵盖一抗、二抗、蛋白质、ELISA试剂盒、酶以及其他用于研究的试剂盒和工具。无论您是进行学术研究,药物开发,疾病研究还是其它生物学研究,Abbexa的单克隆抗体,多克隆抗体,蛋白质和生物试剂均旨在促进您的研究。如果很难找到合适的抗体来满足您的需求,Abbexa还提供了定制蛋白质,肽和抗体的生产渠道。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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