- 中文名称
Cyclin Dependent Kinase 5 Activator 1 (CDK5R1) Antibody
- 英文名字
- Cyclin Dependent Kinase 5 Activator 1 (CDK5R1) Antibody
- 供应商
- Abbexa
- 产品货号
- abx033654
- 产品报价
- ¥询价/80ul ¥询价/400ul

- 产品说明书
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- 购买方式
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- 产品新闻

- 背景资料
- p35 is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5) ; the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
- 应用类型
- WB, IHC
- 免疫原
- CDK5R1
- 来源宿主
- 兔
- 反应性
- 人
- 保存建议
- 建议收到该Cyclin Dependent Kinase 5 Activator 1 (CDK5R1) Antibody产品后,储存温度为-20°C。避免重复冻融
- 其他
- Abbexa总部位于英国剑桥的剑桥科学园,是一家专业的全球抗体供应商和蛋白质供应商,致力于为生命科学、药物开发和生物技术领域的科学家和研究者提供最佳的客户体验和高质量的产品。产品涵盖一抗、二抗、蛋白质、ELISA试剂盒、酶以及其他用于研究的试剂盒和工具。无论您是进行学术研究,药物开发,疾病研究还是其它生物学研究,Abbexa的单克隆抗体,多克隆抗体,蛋白质和生物试剂均旨在促进您的研究。如果很难找到合适的抗体来满足您的需求,Abbexa还提供了定制蛋白质,肽和抗体的生产渠道。

- 注意
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该页面的中文产品信息的翻译,仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前,请浏览说明书确认。
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