This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.
应用类型
WB
免疫原
TMED10
来源宿主
兔
反应性
人
保存建议
建议收到该Transmembrane Emp24 Domain-Containing Protein 10 (TMED10) Antibody产品后，储存温度为-20°C。避免重复冻融
