- 中文名称
Sonic Hedgehog Protein (SHH) Antibody
- 英文名字
- Sonic Hedgehog Protein (SHH) Antibody
- 供应商
- Abbexa
- 产品货号
- abx015984
- 产品报价
- ￥询价/100ul
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868。
- 产品新闻
- 背景资料
- This gene encodes a protein that is instrumental in patterning the early embryo.It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites.Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar.The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing.More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo.Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres.HPE is manifested by facial deformities.It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities.Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.
- 应用类型
- ELISA, WB, IHC, FCM
- 免疫原
- Sonic Hedgehog Protein (SHH)
- 来源宿主
- 小鼠
- 反应性
- 人，小鼠, 猴子
- 保存建议
- 建议收到该Sonic Hedgehog Protein (SHH) Antibody产品后，储存温度为-20°C。避免重复冻融
- 其他
- Abbexa总部位于英国剑桥的剑桥科学园,是一家专业的全球抗体供应商和蛋白质供应商,致力于为生命科学、药物开发和生物技术领域的科学家和研究者提供最佳的客户体验和高质量的产品。产品涵盖一抗、二抗、蛋白质、ELISA试剂盒、酶以及其他用于研究的试剂盒和工具。无论您是进行学术研究,药物开发,疾病研究还是其它生物学研究,Abbexa的单克隆抗体,多克隆抗体,蛋白质和生物试剂均旨在促进您的研究。如果很难找到合适的抗体来满足您的需求,Abbexa还提供了定制蛋白质,肽和抗体的生产渠道。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
-
