Phospho-PDCD4 (Ser457) Antibody detects endogenous levels of PDCD4 only when phosphorylated at Serine 457. This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.
