Phospho-p70 S6 Kinase beta (Ser423) Antibody detects endogenous levels of p70 S6 Kinase beta only when phosphorylated at Serine 423. This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B).