Phospho-Smad3 (Ser213) Antibody detects endogenous levels of Smad3 only when phosphorylated at Serine 213. Smad3 transcription factor phosphorylated and activated by TGF-beta-type receptors. A receptor-regulated Smad (R-smad). Binds directly to consensus DNA-binding elements in the promoters of target genes. In mouse required for establishemnt of the mucosal immune response and proper development of skeleton.
