Phospho-PKC delta (Ser645) Antibody detects endogenous levels of PKC delta only when phosphorylated at Serine 645. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways.