Phospho-IRS-1 (Ser312) Antibody detects endogenous levels of IRS-1 only when phosphorylated at Serine 312. IRS-1 is an adaptor protein that is one of the major substrates of the insulin receptor kinase. Contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain-containing proteins including phosphatidylinositol 3-kinase p85 subunit and GRB-2.
