Phospho-BTK (Tyr223) Antibody detects endogenous levels of BTK only when phosphorylated at Tyrosine 223. Defects in the Bruton tyrosine kinase (BTK) gene cause Agammaglobulinemia. Agammaglobulinemia is an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. [provided by RefSeq]
