Breast Cancer Type 1 Susceptibility Protein Phospho-Ser988 (BRCA1 pS988) Antibody-Breast Cancer Type 1 Susceptibility Protein Phospho-Ser988 (BRCA1 pS988) Antibody代理/参数/厂家-一抗-艾美捷科技有限公司

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中文名称: Breast Cancer Type 1 Susceptibility Protein Phospho-Ser988 (BRCA1 pS988) Antibody

英文名字: Breast Cancer Type 1 Susceptibility Protein Phospho-Ser988 (BRCA1 pS988) Antibody

背景资料: BRCA1 (pS988) Antibody is a Rabbit Polyclonal antibody against BRCA1 (pS988). This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

免疫原: Breast Cancer Type 1 Susceptibility Protein Phospho-Ser988 (BRCA1 pS988)

保存建议: 建议收到该Breast Cancer Type 1 Susceptibility Protein Phospho-Ser988 (BRCA1 pS988) Antibody产品后，储存温度为-20°C。避免重复冻融

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