- 中文名称
Beclin-1 多克隆抗体
- 英文名字
- Beclin-1 polyclonal antibody
- 供应商
- Viva Bioscience
- 产品货号
- VB3166-50
- 产品报价
- ￥4375/50ug
- 产品说明书
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- 产品新闻
- 背景资料
- Beclin-1, the mammalian orthologue of yeast Atg6, has a central role in autophagy. It interacts with a number of cofactors to regulate the lipid kinase VPS34 protein and promote formation of Beclin-1-VPS34-p150 core complexes, thereby inducing autophagy. During phagophore formation, the Vps34 complex contains Atg14L, whereas during maturation into an autolysosome in mammals the complex includes UVRAG. Additional modulating proteins in mammalian cells include AMBRA1, BIF1, RUBICON and HMGB1.
The BH3 domain of Beclin-1 is bound to, and inhibited by Bcl-2 or Bcl-XL. This interaction can be disrupted by phosphorylation of Bcl-2 and Beclin-1, or ubiquitination of Beclin-1. In addition, caspase-mediated cleavage of Beclin-1 promotes crosstalk between apoptosis and autophagy. Beclin-1 dysfunction has been implicated in many disorders, including cancer and neurodegeneration.
- 应用类型
- 免疫原
- Peptide derived from N-terminal region of human beclin-1 protein
- 来源宿主
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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