Potent, irreversible, highly specific inhibitor of deubiquitinating enzymes (DUBs). Utility in the stabilisation of ubiquitin conjugates in cell lysates and tissue extracts and as a control inhibitor for the testing and characterisation of potential DUB activity modulators. Acts as a DUB active site specific probe facilitating detection of DUBs in biological samples.
UbVS has been shown to exhibit differential specificity for particular DUB enzymes compared to other similar ubiquitin C-terminal derivative DUB probes (UbVME, VB2914
