Ubiquitin C-terminal hydrolases (UCHs) are a family of deubiquitinating enzymes (DUBs) that catalyse the hydrolysis of amides, esters and thioesters of the C-terminus of ubiquitin. Mammalian neuronal cells abundantly express ubiquitin carboxy-terminal hydrolase 1 (UCHL1, also known as PGP9.5). Mutations in UCHL1 are linked to Parkinson
