- 中文名称
UBE2S 蛋白(人) (GST标签)
- 英文名字
- UBE2S protein(human) (GST tag)
- 供应商
- Viva Bioscience
- 产品货号
- VB2530-100
- 产品报价
- ￥3250/100ug
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- UBE2S is a member of the ubiquitin E2 conjugating enzyme family, essential components of the ubiquitin cascade.
The selectivity of the ubiquitin cascade for a particular substrate protein relies on the interaction between the E2 conjugating enzyme (of which a cell contains relatively few) and an ubiquitin E3 ligase, of which over 600 have been identified to date. The specific E2-E3 pair required for ubiquitination of a particular substrate protein in vivo may also control the type of ubiquitin modification (mono-, multi-, poly-ubiquitin), the exact substrate lysine residue(s) to be modified and, in the case of polyubiquitination, the chain length and lysine linkage type.
K11-linked ubiquitin molecules are abundant in vivo and, as for K48-linked chains, are thought to be efficient signals for proteasomal degradation. The human anaphase-promoting complex (APC/C) has been shown to assemble K11 linkages on its substrates, utilizing the E2 conjugating enzymes Ube2C (UbcH10) and Ube2S in the process. This suggests a key role for K11-linked ubiquitin chains and Ube2S in cell cycle progression. Overexpression of Ube2S has been linked to tumour cell proliferation and metastasis through its effects on the pVHL-HIF pathway.
Recombinant protein expressed with N-terminal GST-tag. Protein has utility in ubiquitination reactions, polyubiquitin chain synthesis and identification of substrate specific E2-E3 pairs.
- 序列
- Q16763
- 来源宿主
- 溶解建议
- 1 mg/mL
- 保存建议
- 其他
- Ӣ
- 注意
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