Selective inhibitor of c-Jun N-terminal kinase (JNK). Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40-90 nM). Shown to have reduced selectivity over other protein kinases under certain conditions.
Inhibits autophagy through disruption of JNK phosphorylation of Bcl-2, a step required for Beclin-1 activation for subsequent participation in autophagosome formation.
