Cell permeable, selective Hsp90 inhibitor. Binds to the ATP site of Hsp90 (Kd = 1.2 uM) and inhibits its chaperone activity. Consequently downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases. Hsp90 inhibition leads to autophagy activation resulting in the degradation of substrates such as the NFkB pathway activator IKK.
产品描述
Inhibitor of Hsp90 chaperone activity. Autophagy activator
